LeHavreV1, Main, Exploration, bibRecord, 000797

Brain cytochrome P450 aromatase activity in roach (Rutilus rutilus): seasonal variations and impact of environmental contaminants.

Identifieur interne : 000797 ( Main/Exploration ); précédent : 000796; suivant : 000798

Brain cytochrome P450 aromatase activity in roach (Rutilus rutilus): seasonal variations and impact of environmental contaminants.

Auteurs : Perrine Geraudie [France] ; Nathalie Hinfray ; Marie Gerbron ; Jean-Marc Porcher ; François Brion ; Christophe Minier

Source :

Aquatic toxicology (Amsterdam, Netherlands) [ 1879-1514 ] ; 2011.

RBID : pubmed:21820384

English descriptors

KwdEn :
- Animals, Aromatase (metabolism), Biomarkers (metabolism), Brain (drug effects), Brain (enzymology), Cyprinidae (metabolism), Disorders of Sex Development (chemically induced), Endocrine Disruptors (toxicity), Environmental Exposure (adverse effects), Estradiol (metabolism), Female, Male, Ovary (drug effects), Ovary (physiology), Seasons, Sexual Maturation (drug effects), Testosterone (analogs & derivatives), Testosterone (metabolism), Vitellogenins (metabolism), Water Pollution, Chemical (adverse effects).
MESH :
- chemical , analogs & derivatives : Testosterone.
- chemical , metabolism : Aromatase, Biomarkers, Estradiol, Testosterone, Vitellogenins.
- adverse effects : Environmental Exposure, Water Pollution, Chemical.
- chemically induced : Disorders of Sex Development.
- drug effects : Brain, Ovary, Sexual Maturation.
- enzymology : Brain.
- metabolism : Cyprinidae.
- physiology : Ovary.
- chemical , toxicity : Endocrine Disruptors.
- Animals, Female, Male, Seasons.

Abstract

P450 aromatase catalyses the conversion of C19 androgens to C18 estrogens which is thought to be essential for the regulation of the reproductive function. In this study, brain aromatase activity (AA) was measured monthly over a reproductive cycle in wild roach (Rutilus rutilus) sampled in a reference site in Normandy. AA peaked during the breeding season, reaching 35 fmol mg(-1)min(-1) in both male and female fish, and was low during the rest of the year except for a significant rise in October. AA was correlated with ovary maturation (measured either as gonado-somatic index or by histological analysis of the gonads) and plasma sex-steroid levels (11-ketotestosterone in males and 17-β-estradiol in females). Measurements of AA in polluted sites showed that activity was significantly upregulated in sites with fish showing high levels of plasma vitellogenin and large proportion of intersexuality (20-50%) thus suggesting the occurrence of estrogenic compounds and their involvement in AA modulation.

DOI: 10.1016/j.aquatox.2011.07.009
PubMed: 21820384

Affiliations:

Le document en format XML

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<author><name sortKey="Gerbron, Marie" sort="Gerbron, Marie" uniqKey="Gerbron M" first="Marie" last="Gerbron">Marie Gerbron</name>
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<author><name sortKey="Porcher, Jean Marc" sort="Porcher, Jean Marc" uniqKey="Porcher J" first="Jean-Marc" last="Porcher">Jean-Marc Porcher</name>
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<author><name sortKey="Brion, Francois" sort="Brion, Francois" uniqKey="Brion F" first="François" last="Brion">François Brion</name>
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<term>Cyprinidae (metabolism)</term>
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<term>Endocrine Disruptors (toxicity)</term>
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<term>Sexual Maturation (drug effects)</term>
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<term>Vitellogenins (metabolism)</term>
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<term>Male</term>
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<front><div type="abstract" xml:lang="en">P450 aromatase catalyses the conversion of C19 androgens to C18 estrogens which is thought to be essential for the regulation of the reproductive function. In this study, brain aromatase activity (AA) was measured monthly over a reproductive cycle in wild roach (Rutilus rutilus) sampled in a reference site in Normandy. AA peaked during the breeding season, reaching 35 fmol mg(-1)min(-1) in both male and female fish, and was low during the rest of the year except for a significant rise in October. AA was correlated with ovary maturation (measured either as gonado-somatic index or by histological analysis of the gonads) and plasma sex-steroid levels (11-ketotestosterone in males and 17-β-estradiol in females). Measurements of AA in polluted sites showed that activity was significantly upregulated in sites with fish showing high levels of plasma vitellogenin and large proportion of intersexuality (20-50%) thus suggesting the occurrence of estrogenic compounds and their involvement in AA modulation.</div>
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Brain cytochrome P450 aromatase activity in roach (Rutilus rutilus): seasonal variations and impact of environmental contaminants.

Brain cytochrome P450 aromatase activity in roach (Rutilus rutilus): seasonal variations and impact of environmental contaminants.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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